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Developmental analysis by histology, histochemistry, and SEM revealed a significant reduction in acellular cementum formation on Bsp-/-. Acellular extrinsic fiber cementum: a thin layer typically of μm thickness extending from the coronal extent of the root throughout, consisting of a mineralized. Acellular cementum Cellular cementum First formed cementum Formed after acellular cementum Most of it is formed before the tooth.

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The structure of CIFC will be described in detail in the following section. The finger-like processes, arranged in parallel with the cementum surface, were formed on the cementum-facing side of the wing-like processes. Transmission electron micrograph showing the extrinsic fiber-rich CIFC surface in a tangential section through the cementum surface. Chronic periodontitis Localized aggressive periodontitis Generalized aggressive periodontitis Periodontitis as a manifestation of systemic disease Periodontosis Necrotizing periodontal diseases Abscesses of the periodontium Combined periodontic-endodontic lesions.

They are not simple straight fiber bundles, and show branching and anastomosing Fig. If EMT does not occur, how can the cell number reduction be explained?

University of Pennsylvania and Temple University. Cells Tissues Organs Evaluation acellupar two different methylmethacrylate processing, infiltration, and embedding techniques on the histological, histochemical, and immunohistochemical analysis of murine bone samples. Bone sialoprotein is localized to the root surface during cementogenesis.

Generally, acellular cementum is thin and covers the cervical root, whereas thick cellular cementum covers the apical root Fig. Biochem Biophys Res Commun. Dental anatomy and embryology. Thereafter, an intensely hematoxylin-stainable, PAS-positive matrix appears in the superficial dentin layer and forms the cemento-dentinal junction [27][32][33][34] aceplular, [35]. Acellular cementum forms as a progressive mineralization of the PDL collagen fiber bundles inserting into the root surface.


Histomorphometry was used to quantify cementum, root-lining cells, and epithelial attachment, and statistical analysis was performed by independent-samples t test. A functional periodontal complex depends on stable insertion of PDL collagen fibers into the acellular cementum, as well as ability for remodeling on the bone surface of the PDL space.

Cementum on the root ends surrounds the apical foramen and may extend slightly onto the inner wall of the pulp canal. It has the highest fluoride content of all mineralized tissue.

This hypothesis will be referred to as an alternative epithelial hypothesis [45]. Summary Cementum was first demonstrated by microscopy, about years ago. Enamel-matrix, cementum development and regeneration. In some portions, findings from rat cementogenesis will be used supplementally and to a minimum. BSP protein is localized to alveolar bone and to acellular and cellular cementum covering the cervical and apical portions of the molar, respectively Figs.

The external dentin is mineralized much faster than in AEFC genesis. As a result, the intrinsic fibers encircle the extrinsic fibers in extrinsic fiber-rich CIFC [18][53][54]. J Biol Buccale The structural correlation of the extrinsic fibers and dentin matrix fibers at the cemento-dentinal junction has been often disputed. Three possible origins have been proposed [7]: At 14 post-natal days dpna basophilic layer of acellular cementum covered the root dentin in WT mice Figs.

Retrieved 1 December If this is true, connective tissue cells must replace reduced enamel epithelium. The cementum is the part of the periodontium that attaches the teeth to the alveolar bone by anchoring the periodontal ligament. Similar examples of periodontal degradation have resulted in transgenic mouse models with compromised periodontal function, e.

Cementum – Classification | School of Dental Medicine | University of Pittsburgh

Based on the fact that epithelial cells undergoing EMT co-express vimentin and keratin [60][61]Thomas [62] proposed that the cultured epithelial sheath cells transformed into mesenchymal cementim, and further that epithelial sheath cells similarly transformed into cementoblasts through EMT during in vivo normal cementogenesis. At the forming root tip Hertwig’s epithelial root sheath proliferates and grows apically, inducing dental papilla cells to differentiate into odontoblasts. From Wikipedia, the free encyclopedia.


Primary cemetnum included rabbit anti-BSP 1: Cellular cementum size cementumm undiminished by the loss of BSP, though mineralization was delayed at earlier ages; functional consequences of this are under study. At the same time they secrete intrinsic fibers IF along the finger-like processes. As a result, due to the discrepancy in surface area, the epithelial sheath is stretched out and fragmented into epithelial cell rests of Malassez.

Cementum – Classification

In brief, the epithelial origin hypothesis is based on the following logic [29][30][31]. Support Center Support Center.

Intrinsic fibers and cementoblasts CB surround principal fibers. Higashi Nippon Dent J. Discussion BSP is an extracellular matrix protein present in bone and cementum.

In addition, many epithelial sheath cells are embedded near the cemento-dentinal junction in rat cellular cementogenesis [36][37]. Cellular cementum is a more bone-like tissue covering apical portions of roots.

The finding that BSP was present in cementum and strongly expressed by cementoblasts led to speculation that this protein might contribute to cementum formation and mineralization Somerman et al.

From these findings the following was suggested Fig.