La maladie de Huntington est une affection dégénérative du cerveau d’origine I -Présentation de la chorée de Huntington et description de ses troubles. La clozapine, antipsychotique atypique, semble efficace sur les symptômes psychotiques liés à la chorée de Huntington. Nous rapportons le cas d’une patiente. PDF | On, R. de Diego Balaguer and others published ASPECTS CLINIQUES ET NEUROPSYCHOLOGIQUES DE LA MALADIE DE HUNTINGTON.
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If these are abrupt and have random timing and distribution, they suggest a diagnosis of HD.
One X-linked disorder of this type is McLeod syndrome. These implications include the impact on hkntington individual’s psychology, career, family planning decisions, relatives and relationships.
Disease-modifying strategies can be broadly grouped into three categories: International Review of Neurobiology. American Journal of Insanity.
Thanks to the HDF, the ongoing US-Venezuela Huntington’s Disease Collaborative Research Project was started inand reported a major breakthrough in with the discovery of the approximate location of huntingtoj causal gene.
Early damage is most evident in the striatumbut as the disease progresses, other areas of the brain are also more conspicuously affected. Retrieved 18 November Huntington’s Outreach Project for Education, at Stanford.
Retrieved 24 July Reported impairments range from short-term memory deficits to long-term memory difficulties, including deficits in episodic memory of one’s lifeprocedural memory of the body of how to perform an activity and working memory. Archived from the original on 14 July Retrieved 18 April Postpartum depression Postpartum psychosis.
Physical therapists also prescribe breathing exercises and airway clearance techniques with the development of respiratory problems. X-linked intellectual disability Lujan—Fryns syndrome. The interactions of the altered huntingtin protein with numerous proteins in neurons leads to an increased vulnerability of glutamine, which, in large amounts, has been found to be an excitotoxin. Some HD research has ethical issues due to its use of animal testing and embryonic stem cells.
From Wikipedia, the free encyclopedia. The highest concentrations are found in the brain and testeswith moderate amounts in the liverheart huntkngton, and lungs. Huntington’s disease cyoree autosomal dominant inheritance, meaning that an affected individual typically inherits one copy of the gene with an expanded trinucleotide repeat the mutant allele from an affected parent.
Radiology picture of the day. The first thorough description of the disease was by George Huntington in Also covered is information concerning family planning choices, care management, and other considerations.
Huntington’s disease – Wikipedia
The Huntington’s disease mutation is genetically dominant and almost fully penetrant: Neurology, Psychiatry and Brain Research 8: Genetic Disorders Sourcebook 3rd ed.
Archived from the original on 5 March Hutington is one of several trinucleotide repeat disorders which are caused by the length of a repeated section of a gene exceeding a normal range.
Archived from the original on 18 February Archived from the original on 22 October Tetrabenazine was approved in for treatment of chorea in Huntington’s disease in the EU, and in in the US. Retrieved 12 May Archived from the original on 27 July Huntington’s was given different names throughout this history as understanding of the disease changed. To initiate a particular movement, the cerebral cortex sends a signal to the basal ganglia that causes the inhibition to be released.
The clinical improvment was associated with plasma levels of clozapine which have been recognized as in therapeutic ranges by previous studies. A lower daily dose than those classicaly used in schizophrenia was sufficient to obtain efficient treatment.
Archived from the original on 4 July Because HD follows an autosomal dominant pattern of inheritance, there is a strong motivation for individuals who are at risk of inheriting it to seek a diagnosis. Archived from the original on 22 January