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PI = Prescribing Information / SUV = Single Use Vial / SDV = Single Dose Vial / MDV = Multi Dose Vial / N/A: Not Applicable / LF: Latex Free / PF: Preservative. Medscape – Indication-specific dosing for colistimethate sodium, Coly Mycin M ( colistin), frequency-based adverse effects, comprehensive interactions. Drug Information on Coly Mycin M (colistimethate) includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to.

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In animal studies, colistin base is tightly bound to cell membranes in the liver, lung, kidney, brain, heart, and muscles.

Subscribe to free Drugs. Reconstitute vial with 30 mL of sterile 0. Use within 7 days. Peritoneal dialysis Case reports indicate that colistimethate sodium given intraperitoneally is absorbed, but concentrations are not consistent with systemic use; limited drug is removed during peritoneal dialysis.

The patient expired 43 days after therapy ended due to cardiac arrest; however, postmortem showed no evidence of infection. Moderate Tenofovir-containing products should be avoided with concurrent or recent use of a nephrotoxic agent, such as colistimethate sodium. If the term colistin is used, then the information described applies to both products.

Synergistic activity against gram-negative microorganisms has been shown with tetracyclines, chloramphenicol, and the beta-lactams. Administer 10 mg 3 mL via external ventricular drain clamped for 1 to 3 hours after the removal of greater or equal volume of CSF. The body weight used should be the lower of either ideal or actual col weight. Vials for injection containing colistimethate sodium equivalent to mg colistin base activity are used off-label for nebulization.


Tell your doctor if you are pregnant or plan to become pregnant.

Peak breast milk mycib occurred 5 hours post-dose. Studies suggest that the main resistance mechanism involves alterations of the outer membrane of the bacterial cell. One study found that the use of colistin as well as other broad-spectrum antimicrobials, such as monolactams and third-generation cephalosporins, were significant risk factors for colistin-resistant isolates.

For the treatment of meningitis or ventriculitis due to susceptible organisms. The half-life of colistin is reported to be 2 to 3 hours; however, older studies determining the pharmacokinetic mycun of colistin were based on microbiological assays for measuring drug concentrations; therefore, this may represent the composite values representing the summed half-lives of colistimethate sodium and colistin sulfate.

Colistin has shown in vitro activity for Acinetobacter sp.

Coly Mycin M Uses, Side Effects & Warnings –

The following recommendations mtcin based on an interim study of critically-ill patients. The FDA-approved dosage is 2. Tell your doctor if you are breast-feeding. For continuous IV infusion, administer one-half of the total daily dose IV bolus over 3 to 5 minutes, then 1 to 2 hours later give the remainder of the daily dose by continuous IV infusion over 22 to 23 hours.

Generally, colistin does not penetrate well into the pleural cavity, lung parenchyma, bones, and CSF based on older studies. The colistin Css,avg target should be based on the MIC, site of infection, and severity of infection. Related Drug Information Drug Summary.

In one study in patients with cystic mycib receiving colistin as 7. Colistimethate sodium is used for parenteral administration, given via intravascular IM injection, IV injection, or IV infusionintrathecal or intraventricular administration.


Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Single dose studies in human pregnancy show that colistimethate sodium crosses the placental barrier and there may be a risk of fetal toxicity if repeated doses are given to pregnant patients.

A year-old boy was treated with colistimethate sodium equivalent to 5 mg colistin base activity intraventricularly twice daily for 20 days for Acinetobacter baumannii ventriculitis. For intermittent IV infusion: Therefore, the possibility of systemic absorption should always be borne in mind when treating patients by inhalation.

Colistimethate sodium is classified as FDA pregnancy category C. However, a study in cystic fibrosis patients showed that colistimethate sodium was undetectable in the urine after 3 months of daily use indicating minimal absorption renal elimination is the main route of excretion.

Coly Mycin M

Therefore, use colistimethate sodium during pregnancy only if the potential benefit justifies the potential risk voly the fetus. Lamivudine; Tenofovir Disoproxil Fumarate: This may increase the potential for nephrotoxicity; therefore, the authors suggest using this maintenance dose formula in patients with good renal function only if the target Css,avg is low.

In a single-dose study ckly 29 women, 9 women received colistimethate sodium 1 million international units IM and 20 women received 2 million international units IM.

Major Colistimethate sodium should be used cautiously in patients receiving cisplatin.