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Diazotization Titration or Nitrite Titration. Diazotization is used in the analysis of aromatic compounds containing an amino group in the. View Notes – from ECH at University of Florida. Diazotization titration (Nitrite Titration) Mr. V. M. Patil Assistant Professor & PG. Quantitative estimation of Eflornithine by Nitrite (Diazotization) titration Here the amino group of Eflornithine is diazotized with sodium nitrite solution in.

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There are mainly three types of methods based on the titration procedure. Published by Walter Moore Modified over 3 years ago. Then concentrated hydrochloric acid and potassium bromide are added and the rest of the volume is filled with the distilled water.

Then the solution is slowly titrated with the 0. Reaction time it takes 10—15 min: This method is first used in the determination of dyes. The point where the EMF increases rapidly gives the end point. They are as follows: The principle involved in this method is that the primary aromatic amine present in the sample reacts with the sodium nitrite in the presence of acid such as hydrochloric acid to obtain a diazonium salt.

4. Diazotization Titrations – Pharmaceutical Analysis [Book]

The liberated iodine is back titrated with the sodium thiosulphate using starch as the external indicator. Start Free Trial No credit card required. My presentations Profile Feedback Log out. This information is too useful and my request to you that give some information about errors chapter.

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What titrwtion the principle involved in the diazotization titrimetry? With Safari, you learn the way you learn best.

What are the example duazotization assayed by the diazotization titrimetry? What is a chemical reaction? Volumetric Analysis Volumetric analysis is when the volume of a reactant required to complete a chemical reaction is measured. Potentiometric Electrodes Potentiometric electrodes measure: The main principle involved in this method is to treat the amino group containing drug with the acid solution.

Unknown 5 October at At the end point, permanent deflection of the galvanometer is observed. To use this website, you must agree to our Privacy Policyincluding cookie policy. Labels Diazotization Titrations free pharmacy study material pharmaceutical analysis pharmaceutical analysis lecture notes.

We think you have liked this presentation. Vorlander first proposed the non-aqueous titration method that is titration diazltization aniline with the HCl in non-aqueous solvent, that is, benzene.

What are the advantages of diazotization titrimetry? Lowitz first prepared the moisture-free solvents non-aqueous solvents. The amine reacts with the nitrous acid to form nitrosamine, which is followed by the tautomerisation and the water molecule is lost diazotizarion form the diazonium ion. The percentage amount of the sulpha drug is determined by the following equation: The principle involved in this method is that the primary aromatic amine present in the sample reacts with the sodium nitrite in the presence of acid such as hydrochloric acid to obtain a diazonium salt.

Then the solution is titrated with the sodium nitrite solution until the starch iodide paper turns into blue colour.

Pharmaceutical Analysis by P. D. Chaithanya Sudha

The main principle …. The titrationn rate is increased by the addition of the potassium bromide solution. Sulphanilic acid and anthranilic acid. Used in the determination of the amphetamine. Then this solution is titrated with the sodium nitrite solution.

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Used in the determination of the ephedrine.

A Seminar on Potentiometric and Diazotization Titrations

Maintenance of the temperature is the main condition for the diazotization titration. The end point is determined by streaking one drop of the titration solution on the starch iodide paper until blue colour is appeared.

When sodium nitrite is reacted with the hydrochloric acid sodium chloride and nitrous acid are formed. The general procedure is followed by weighing the sample and transferring it into the standard flask.

This resulting solution is known as the standard solution. Fritz first used this method to distinguish the aromatic and aliphatic amines by using the perchloric acid as titrant.

Diazotization Titrations

Applicable for a very less variety of samples. After diazotization, one drop of the resulting solution is placed on the starch iodide paper which changes into dark colour. Share buttons are a little bit lower. Auth with social network: Addition of sodium nitrite to the sample solution takes time to react with the amino group present in the sample solution.

The principle involved in this method is that the excess nitrous acid is added to the titration sample solution and it is back titrated with the other appropriate titrant.