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Title, Evolution by gene duplication. Author, Susumu Ohno. Edition, illustrated. Publisher, Springer-Verlag, Original from, the University of Michigan. Title, Evolution by Gene Duplication. Author, Susumu Ohno. Edition, illustrated. Publisher, Allen & Unwin, ISBN, , The genome of S. cerevisiae is characterized by a high genetic redundancy which can largely be attributed to a whole genome duplication event (Ohno, ;.

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Functional divergence between the duplicate genes is another possible fate. The major criticism of this model is the high likelihood of non-functionalization, i.

The intermediate evolutionary result could be a multi-functional gene and after a gene duplication its sub-functions could be carried out by specialised descendants of the gene.

Evolution by gene duplication – Wikipedia

This made it possible to appreciate the repeating nature of motifs in the DNA sequence in a much more pleasant fashion than scanning the monotonous repeating letters of the sequences. The second child was a daughter, Yukali, who studied philosophy and now lives with her husband in Hawaii.

His love of animals, particularly of horses, proved to be one of the most pervasive influences in his life. Review articles on this topic can be found at the bottom. DDC stands for “duplication-degeneration-complementation”. Sex-linkage of the glucosephosphate dehydrogenase gene in Equidae.

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When beginning his work at the City of. The duplication becomes permanently established in the genome of the host cell or organism.


Do you enjoy reading reports from the Academies online for free? In such a case, the molecular function e. But he found that this was not the case in organisms lower on the phylogenetic tree.

Susumo Ohno | Biographical Memoirs: V | The National Academies Press

Sign up for email notifications and we’ll let you know about new publications in your areas of interest when they’re released. Biographic Memoirs Volume 81 contains the biographies of deceased members of the National Academy of Sciences and bibliographies of their published works. This enzyme is capable of catalyzing not only its original function, but also side function that can carried out by other enzyme.

Ohno was fascinated by the testicular feminization syndrome, in which XY persons do not only develop into phenotypic females but into females who are particularly beautiful.

This page only presents which theoretical models are currently discussed in the literature. He then weighed the cutout chromosomes showing in this way that whether there were 17 pairs of chromosomes as in the creeping vole, Microtus oregoni, or 84 pairs as in the black rhinoceros, the amount of chromosomal material was the same.

Thus, he recognized that this DNA could serve as a powerful means by which new genes or new functions of old genes could be created. Based on feedback from you, our users, we’ve made some improvements that make it easier than ever to read thousands of publications on our website. Evolution of new functions de novo and from preexisting genes.


While these studies hardly foretold the profound insights that Ohno would have into biologic mechanisms, they established him as a highly skilled experimentalist. X-autosome ratio and the behavior pattern of individual X-chromosomes in placental mammals. If the amount of gene product is below its optimal level, there are two kinds of mutations that can increase dosage: The preface of the first of these books reads as follows: The family returned to Japan after the war in A mutation evolugion the X chromosome that causes resistance to the effect of male hormones is responsible for this disorder.

Susumu Ohno

Views Read Edit View history. The term neofunctionalization was first coined by Force et al.

The youngest son lives in Las Vegas, where he sksumu as a croupier. In addition, he was taught by tutors to learn Chinese language and Chinese history.

From Wikipedia, the free encyclopedia. This name first appeared in a publication ihno Hittinger and Carroll Gene dosage effects after duplication can also be harmful to a cell and the duplication might therefore be selected against.