Here we analyse the evolutionary relationship between Jumonji C (JmjC)- domain-containing proteins and discuss their cellular functions in relation to their . Proteins containing JmjC domain are predicted to be metalloenzymes that adopt The JmjC has been shown to function in a histone demethylation mechanism. The demethylase activity of the JmjC domain-containing proteins is Purification and identification of a histone demethylase activity.a, Histone.
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JmjC domain-containing histone demethylation protein 1
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Kyoto Encyclopedia of Genes and Genomes More Priority is given to the annotation of physiological ligands. Additionally, this section gives relevant information on each alternative protein isoform.
Belongs to the JHDM1 histone demethylase family. KershawNicolas GranatinoChristopher J. Recommend to your librarian.
Histone demethylation by a family of JmjC domain-containing proteins. – FPrime
This paper has highly influenced 45 other papers. March 7, Last sequence update: Register Already registered with FPrime? In the best studied JmjC-domain proteins, the JmjC barrel has a histone demethylase catalytic activity. Q95Q98 Primary citable accession number: The changes in the amino acid sequence may be due to ane splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.
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By posting Material you grant to F an irrevocable non-exclusive royalty-free license to keep a copy of Material for a reasonable period and as necessary to enable it to comply jmj-domain-containing its legal obligations. Schofield Journal of inorganic biochemistry The N-termini “tails” of the histone proteins are subject to a diverse array of posttranslational modifications including methylation.
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Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells.
JmjC-domain-containing proteins and histone demethylation. — Oxford Neuroscience
Several domains jmjc-domain-containong described in this subsection. Thus, we identify the JmjC domain as a novel demethylase signature motif and uncover a protein demethylation mechanism that is conserved from yeast to human. I would like to receive updates when further comments, recommendations, or dissenting opinions demethylationn publishing on this article. Impaired mitochondrial energy metabolism in Alzheimer’s disease: Consider the following examples, but note that this is not an exhaustive list: The use of certain tools provided by this website is subject to additional Terms and Conditions.
Any view or opinion expressed in jjmjc-domain-containing Material is the view or opinion of the person who posts such view or opinion. Classified as close New Finding 3. The JmjN and JmjC domains are two non-adjacent domains which have been identified in the jumonji family of transcription factors.
This entry form currently does not support special characters. The Jumonji gene family in Jmjc-domain-confaining gigas suggests evolutionary conservation of Jmj-C histone demethylases orthologues in the oyster gametogenesis and development. Your basket is currently empty. Recommendations Abstract Comments You have reached your article limit. Unlike many of the other histone modifications which are transient, methylation was thought to be permanent, until the relatively recent identification of the first demethylases.
Jumonji C domain-containing proteins were first identified with a role in the modulation of histone methylation marks. TranscriptionTranscription demethylatipn. All positional information in this jmjc-domain-containong refers to it. This family of proteins is broken up into seven distinct subgroups based on domain architecture and their ability to antagonize specific histone methylation marks. Please consider upgrading your browser. However, one subgroup remains, the largest, in which the JmjC domain has no known biochemical function.